_the-quest-for-high-confidence-mutations-in-plasma-searching-for-a-needle-in-a-haystack.jpg "The quest for high confidence mutations in plasma: searching for a needle in a haystack from unique identifiers in access Video Screenshot Preview")
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⏲ Duration: 37 min 19 sec
✓ Published: 26-Apr-2018
✓ Published: 26-Apr-2018
Description:
Next generation sequencing (NGS) of circulating tumor DNA (ctDNA) from patient plasma is becoming more widespread in oncology clinical trials. The noninvasive nature of acquiring these samples is particularly important when resection of representative tumor samples is not advised or not possible. However, profiling of ctDNA has challenges to overcome, such as low concentration of ctDNA shed from the tumor and a low signal:noise ratio caused by somatic alterations with less than 1% variant allele
Next generation sequencing (NGS) of circulating tumor DNA (ctDNA) from patient plasma is becoming more widespread in oncology clinical trials. The noninvasive nature of acquiring these samples is particularly important when resection of representative tumor samples is not advised or not possible. However, profiling of ctDNA has challenges to overcome, such as low concentration of ctDNA shed from the tumor and a low signal:noise ratio caused by somatic alterations with less than 1% variant allele
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